Project Description

Stem Cell Joint Regeneration

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Stem Cell Joint Regeneration

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What Is Regenerative Medicine?

Regenerative medicine is the process of replacing, renewing or engineering human cells, tissues, organs, proteins, etc for the purpose of restoring function and homeostasis in the body. One of the key components of regenerative medicine is the use of cell replacement strategies which usually requires stem cells.

What Are Stem Cells?

These are undifferentiated cells in our bodies that have the capacity to change into any healthy cell in our body. Meaning they can change into skin, bone, heart and muscle cells to name a few. They have the ability to replicate substantially as compared to normal somatic cells such as skin. Stem cells are located throughout our body in almost every organ and tissue such as bone marrow, fat, teeth, muscles, etc. However, as other cells in our body, stem cells also age as we do.

Why We Only Use Liveyon?

Liveyon uses only umbilical cord-derived regenerative medicine products. This causes no pain for the patient as there is no extraction or procedure required to obtain the stem cell-based product. Moreover, the product contains no known proteins that can cause rejection in your patient. Research has shown that umbilical cord-derived stem cells are not susceptible to malignant transformation in a serum-free medium, making them safe for therapeutic use in patients.

Our regenerative medicine product is produced in a cGMP lab that receives all cord tissue/blood donations from hospitals directly to the facility, which guarantees minimal handling and a lower risk of cell loss or contamination. Our regenerative medicine product is produced in compliance with FDA cGMP (Current Good Manufacturing Practice) and GTP (Good Tissue Practices) standards, which assures you the end user quality and safety in our product. Most importantly, our regenerative medicine product is minimally manipulated preserving its natural healing properties.

Liveyon’s regenerative medicine product is easily shipped and once delivered yields consistent concentrations allowing for multiple administrations in uniform, high-cell-count doses. Patients can enjoy safe, non-surgical treatments in the time it would take them for a traditional office visit.

Liveyon’s ReGen® Series contains stem cells. Our characterized product contains mesenchymal stem cells (MSCs). These are defined by the stem cell marker CD90. Moreover, they are negative for HLA-DR which helps you feel comfortable that your patient will not have any negative reactions to the product.

OUR PRODUCT IS GUARANTEED TO MEET OR EXCEED SPECIFICATIONS LISTED

Our Product is Guaranteed to meet or Exceed Specifications Listed LIVEYON’s regenerative medicine product provides doctors with a specific concentration of cells listed on the product sheet. Moreover, we offer customizable quantities for individual applications. This makes you confident that you are delivering precisely a specific amount. We stand by our regenerative medicine product 100%.

Stem Cell History

Stem cells have been around for well over a century. In fact, the term stem cell was used as early as 1868 and in 1909, Alexander Maximow lectured at the Berlin Hematological Society on a theory that all blood cells come from the same ancestor cell…..a stem cell. In 1968, the first bone marrow transplant occurred which was successful due to stem cells in the bone marrow. In 1978, stem cells were discovered in human cord blood.

From here on, there were many new types of stem cells discovered and the world of regenerative medicine commenced to take shape and show much promise. Presently, stem cells have the capacity to replace bone, fat, cartilage, heart tissue, muscle, etc.

This shows much promise for many disease states. In fact, there are greater than 5000 clinical studies with stem cells found on the United States clinictrials.gov website. This demonstrates the progress and promise of stem cells.

How Do Stem Cells Function?

Stem cells have the capacity to migrate to injured tissues, a phenomenon called homing. This occurs by injury/disease signals that are released from the distressed cells/tissue. Once stem cells are delivered to a site of injury or deployed into the blood stream, they go to these distressed signals and dock onto adjacent cells to commence performing their job.

  • They serve as a cell replacement where they change into the needed cell type, such as a muscle cell. This is ideal for traumatic injuries and orthopedic applications.
  • They do not express specific HLAs which help them avoid the immune system. In fact, mesenchymal stem cells (MSCs) do this so well that they are in clinical studies for graft vs host disease and have been approved for pediatric graft vs host disease in Canada. These studies and data support the notion that the cells are safe to use as an “off the shelf” product such as Liveyon’s ReGen® Series.
  • They dock on an adjacent cell and release proteins called growth factors, cytokines and chemokines. These factors help control many aspects such as:
    • Control the immune system and regulate inflammation which is a key mediator of diseases of aging and autoimmune diseases such as rheumatoid arthritis and multiple sclerosis.
    • Help to increase new blood vessel formation which aids in adding vasculature so that tissues can receive proper blood flow and the correct nutrients needed to heal, in cases such as stroke, peripheral artery disease and heart disease.
    • Provide trophic support for surrounding tissues and help host endogenous repair. This works great when used in orthopedics as it causes signals to be released which may now activate your own stem cells to repair a knee for instance. In case of diabetes, it may help any remaining beta cells to reproduce or function optimally.