GLP-1 agonists like Semaglutide help to control your blood sugar, but people taking them also tend to lose weight. GLP-1, the key hormone involved, slows down how fast your stomach empties food (called gastric emptying). And in addition to causing your pancreas to release insulin, Semaglutide also blocks a hormone that causes your liver to release sugar (glucagon). Together, these functions can help you feel less hungry, causing you to eat less food and lose more weight.
Yes, itʼs believed that Semaglutide helps curb your appetite. In addition to slowing gastric emptying to make you feel full longer. GLP-1 also plays a direct role in how appetite is regulated.
With Semaglutide, you will slowly work your way up to the target dose at which time you will see the most amount of weight loss. This was the case in the clinical trials, where participants had their dose adjusted until they reached 2.5 mg dose if needed. In the phase 3 trial that measured outcomes at 20 weeks, most participants were able to reach the full dose and also lost weight as their dose was increased. They saw additional weight loss over the remaining 48 weeks at the full dose. It is important to keep in mind that weight loss can take time, and you'll see the best results when you are using your medication in combination with a healthy diet and exercise. Sometimes the medication may not work for you, or you may not be able to tolerate the full dose due to side effects in which case your practitioner will provide additional options or change the protocol to better suit your individual needs.